Picamilon and Cerebrovascular Disorders

A P Huaichenko, RP Kruglikova-Lvova

[Article in Russian]

Institute of Pharmacology, 
Baltiyakaya st., 8, Moscow, 125315, USSR

Abstract

Picamilon induces a significant increase in cerebral blood flow in conscious animals.  Cerebrovascular effect of picamilon is more potent and durable than that of GABA, nicotinic acid, cinnarizin, nicergoline, xanthinol nicotinate, dihydroetgotoxin, and papaverin.  Under picamilon action there was observed the reduction in neurogenic spasms of cerebrovascular vessels accompanied by the inhibition of tonic activity and reflectory discharges in sympathetic nerves.  Picamilon recovers the cerebral has disturbed by serotonin.